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Dr. Marek Derkacz, MBA

How to deal with adrenal breakthrough. A guide for patients and doctors

MedExpress Team

Dr n. med. Marek Derkacz

Published Jan. 16, 2025 07:14

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Adrenal hyperplasia is a condition of sudden and severe cortisol deficiency that can be immediately life-threatening. It occurs most often in patients with Addison's disease, but can also affect people with secondary or tertiary adrenal insufficiency. Proper preparation and prompt response can save lives. In the following article, I provide comprehensive information on how to recognize adrenal breakthrough, what to do if it occurs, and why having an emergency kit is crucial.

What is adrenal breakthrough and what are its causes?

Adrenal hyperplasia occurs when the body is unable to produce enough cortisol, a hormone responsible for regulating stress response, metabolism, blood pressure and water and electrolyte balance. It can be caused by:

  • Physical stress: infections (e.g., flu, COVID-19), trauma, surgery, severe pain, dehydration.
  • Emotional stress: heavy experiences, sudden changes in life situation.
  • Errors in therapy: skipping drug doses, under-dosing hydrocortisone, failing to adjust the dose in stressful situations.
  • Poisoning: vomiting and diarrhea leading to electrolyte loss and dehydration.

Symptoms of adrenal breakthrough

Recognizing adrenal breakthrough...

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