The study was funded by Janssen and conducted in collaboration with the Aetion Research Department and the Pharmacoepidemiology Laboratory of the Brigham Harvard Medical School Women's Department of Medicine.
The study looked at the protection profiles of all three vaccines authorized (or approved) in the US. For all three preparations, the same methodology was used for the following three parameters: breakthrough infections (ie, cases of sickness in vaccinated subjects), hospitalization, and admission to intensive care units [1].
To date, comprehensive studies on the protection period of vaccines approved or approved for use in the US have been limited, and many have focused on high-risk groups [2], [3], [4], [5] or specific geographic or geographical areas or individual states. [6], [7], [8]
This time, however, we are dealing with an extensive study of the durability of protection against COVID-19 under real conditions in the USA. This is the first study of its kind to analyze the durability of the initial protection up to 6 months for all three vaccines authorized or approved in the US against the following three parameters: COVID-19 breakthrough infections, hospitalization and admission to intensive care units. .
Researchers used national claim data, laboratory and hospital data from 168 million people to conduct a follow-up clinical trial between January 1 and September 7, 2021 for 17 million fully vaccinated people classified by vaccination dates, three-digit zip code , age, sex, and rates of comorbidities. [1]
The study focused on the durability of the protection that vaccination provides. Odds Ratio (OR) measurements were made, which in a fully vaccinated person estimate the likelihood of breakthrough infection, hospitalization or admission to the intensive care unit each month, compared with the probability of such an event occurring in the month following full vaccination. [1] Odds ratio values greater than one indicate that the protection provided by the vaccine declines over time [1].
The authors of the study make a reservation that odds ratio comparisons ...
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